AMEDERA • RESEARCH
These insights are based on trusted scientific research used to build Amedera, with ongoing review as new evidence becomes available. No trends. No extremes. Just what actually works in real life.
Annals of Internal Medicine • Randomized controlled trial (12 months)
A structured 4:3 fasting rhythm led to modestly greater weight loss than daily calorie restriction when people could actually stick to it.
Why this matters
Consistency mattered more than calorie precision.
The BMJ • Systematic review + network meta-analysis
Across trials, intermittent fasting performed similarly to traditional calorie restriction, with outcomes largely driven by adherence.
Why this matters
The best plan is the one you repeat calmly.
Nature Communications • Randomized controlled trial
Flexible time-restricted eating combined with exercise improved metabolic markers more than rigid timing alone.
Why this matters
Flexibility beats rigidity, especially long term.
Science Translational Medicine • Randomized controlled trial (isocaloric)
When calories were kept equal, time-restricted eating shifted circadian signals but did not improve key cardiometabolic outcomes versus control.
Why this matters
Timing isn’t a cheat code. Amedera helps you choose a window you can actually repeat and stick with.
The Lancet Healthy Longevity • Randomized controlled trial
A 10-hour eating window did not meaningfully outperform the comparison approach for preventing weight regain; real-world adherence and consistency were the biggest drivers.
Why this matters
This is exactly why Amedera focuses on adherence: a clear rhythm, a timer, and gentle nudges that keep you consistent.
Cell Metabolism • Peer-reviewed review (human trials + mechanisms)
Overall, intermittent fasting and time-restricted eating can improve weight and cardiometabolic markers for many people, but effects often track with energy intake and how well the routine is sustained.
Why this matters
Premium outcome = fewer decisions. Amedera turns fasting into a repeatable routine, not a willpower contest.
Trends in Cardiovascular Medicine • Systematic review + meta-analysis
Across trials, time-restricted eating was associated with modest improvements in blood pressure and related metabolic markers, with variation by protocol and adherence.
Why this matters
Small, steady wins compound. Amedera is built around realistic windows you can keep through real life.
Annals of Internal Medicine • Randomized controlled trial (3 months)
A personalized 8–10h eating window modestly improved HbA1c versus standard-of-care nutrition counseling, with no major adverse events.
Why this matters
Small, realistic changes done consistently beat extreme protocols. Amedera focuses on a window you can actually live with.
EClinicalMedicine (The Lancet) • Umbrella review of meta-analyses of randomized controlled trials
Across RCT evidence, intermittent fasting generally improves anthropometric and several cardiometabolic outcomes, but results vary by outcome and population.
Why this matters
Good news: IF works for many. Better news: you don’t need extremes. Amedera is built around repeatable rhythms and adherence.
JAMA Network Open • Randomized clinical trial (6 months)
An 8-hour time-restricted eating window without calorie counting led to greater weight loss than calorie restriction and lowered HbA1c; HbA1c changes were similar between TRE and calorie restriction compared with controls.
Why this matters
A simple eating window can replace calorie counting, which makes adherence feel easier and more realistic long-term.
JAMA Network Open • Randomized clinical trial (12 months)
With the same prescribed calorie intake restriction in both groups, 8-hour time-restricted eating (8:00–16:00) did not produce additional benefits versus daily calorie restriction for weight, body fat, or major metabolic risk factors over 12 months.
Why this matters
Timing isn’t a cheat code. Sustainable results come from consistency and overall intake, so Amedera focuses on a realistic rhythm you can keep (not extremes).
Hepatology Communications • Systematic review & meta-analysis
Intermittent fasting was associated with improvements in liver-related endpoints and metabolic markers in pooled analyses, though heterogeneity and long-term data limits remain.
Why this matters
IF can support metabolic health when it’s sustainable. Amedera’s plans are built to reduce drop-off and rebound.
Nobel Prize in Physiology or Medicine • Nobel Prize recognition (foundational cell biology)
Yoshinori Ohsumi’s work identified key genes and mechanisms behind autophagy, a core cellular “recycling” process often discussed in fasting science.
Why this matters
We don’t do hype. Amedera frames ‘autophagy’ as a scientific concept, not a guaranteed outcome you unlock like an achievement badge.
WHY AMEDERA
Consistency over intensity
Research repeatedly shows that sustainable routines outperform aggressive plans.
Flexible, not fragile
Amedera adapts to real schedules instead of forcing perfect fasting windows.
Less thinking, more calm
Clear stages and gentle reminders reduce decision fatigue.
Built for the long run
Not a challenge. Not a reset. A routine you can keep.
Not medical advice. For informational purposes only.
